Synthesis and antimicrobial evaluation of 2-(2-butyl- 4-chloro-1H- imidazol-5-yl-methylene)-substituted-benzofuran-3-ones
نویسندگان
چکیده
In the present study, the oxidation of 3-(4-chloro-1H-imidazol-5-yl)-1-(2-hydroxyphenyl)prop-2-en-1ones with mercuric(II) acetate in in polyethylene glycol (PEG-400) gave the corresponding 2-((4-chloro-1Himidazol-5-yl)methylene)benzofuran-3(2H)-ones. Newly synthesized compounds were tested for their in vitro antimicrobial activity.
منابع مشابه
Synthesis of Novel 2-butyl-1H-benzo [4, 5] imidazo [1, 2-a] imidazo [4, 5-e] Pyridine-5-carbonitrile Derivatives and Evaluation of their Anticancer Activity ACHANTA VENKATA HANUMANTHA RAO, RAYAM PARSHARAMULU, MALTHUM SHANKARAIAH, VADALI LAKSHMAN RAO and ANIREDDY JAYA SHREE *
A series of new 2-butyl-1H-benzo[4,5]imidazo[1,2-a]imidazo[4,5-e]pyridine-5-carbonitrile derivatives were synthesized by the self cyclisation of (E)-2-(1H-benzo[d]imidazol-2-yl)-3-(2-butyl4-chloro-1H-imidazol-5-yl)acrylonitrile in the presence of piperidine as catalyst, which in turn were prepared by the condensation of substituted N-alkyl 2-butyl-4-chloro-1H-imidazole-5-carbaldehydes with 2-cy...
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